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Cleaved high molecular weight kininogen accelerates the onset of endothelial progenitor cell senescence by induction of reactive oxygen species

OBJECTIVE: Cleaved high molecular weight kininogen (HKa), an activation product of the plasma kallikrein-kinin system, inhibits endothelial cell functions. We questioned whether HKa affects the function of endothelial progenitor cells (EPCs) and accelerates their senescence. METHODS AND RESULTS: Tre...

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Main Authors: Dai, Jihong, Zhu, Xuemei, Yoder, Mervin C., Wu, Yi, Colman, Robert W.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089907/
https://ncbi.nlm.nih.gov/pubmed/21252071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.222430
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