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The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction

R-spondins are a recently characterized family of secreted proteins that activate Wnt/β-catenin signaling. Herein, we determine R-spondin2 (Rspo2) function in craniofacial development in mice. Mice lacking a functional Rspo2 gene exhibit craniofacial abnormalities such as mandibular hypoplasia, maxi...

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主要な著者: Jin, Yong-Ri, Turcotte, Taryn J., Crocker, Alison L., Han, Xiang Hua, Yoon, Jeong Kyo
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089906/
https://ncbi.nlm.nih.gov/pubmed/21237142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2011.01.004
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