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Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb
The R-spondin (Rspo) family of protein consists of secreted cysteine-rich proteins that can activate β-catenin signaling via the Frizzled/LRP5/6 receptor complex. Here, we report that targeted inactivation of the mouse Rspo2 gene causes developmental limb defects, especially in the hindlimb. Althoug...
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| Glavni autori: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692258/ https://ncbi.nlm.nih.gov/pubmed/17904116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.08.023 |
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