Monosomy of Chromosome 10 Associated With Dysregulation of Epidermal Growth Factor Signaling in Glioblastomas

CONTEXT: Glioblastomas—uniformly fatal brain tumors—often have both monosomy of chromosome 10 and gains of the epidermal growth factor receptor (EGFR) gene locus on chromosome 7, an association for which the mechanism is poorly understood. OBJECTIVES: To assess whether coselection of EGFR gains on 7...

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Detalhes bibliográficos
Principais autores: Yadav, Ajay K., Renfrow, Jaclyn J., Scholtens, Denise M., Xie, Hehuang, Duran, George E., Bredel, Claudia, Vogel, Hannes, Chandler, James P., Chakravarti, Arnab, Robe, Pierre A., Das, Sunit, Scheck, Adrienne C., Kessler, John A., Soares, Marcelo B., Sikic, Branimir I., Harsh, Griffith R., Bredel, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089898/
https://ncbi.nlm.nih.gov/pubmed/19602687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2009.1022
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