MITOCHONDRIAL OXIDANT STRESS TRIGGERS CELL DEATH IN SIMULATED ISCHEMIA-REPERFUSION

To clarify the relationship between reactive oxygen species (ROS) and cell death during ischemia-reperfusion (I/R), we studied cell death mechanisms in a cellular model of I/R. Oxidant stress during simulated ischemia was detected in the mitochondrial matrix using mito-roGFP, a ratiometric redox sen...

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Main Authors: Loor, Gabriel, Kondapalli, Jyothisri, Iwase, Hirotaro, Chandel, Navdeep S., Waypa, Gregory B., Guzy, Robert D., Hoek, Terry L. Vanden, Schumacker, Paul T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089816/
https://ncbi.nlm.nih.gov/pubmed/21185334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2010.12.008
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