Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G: MOLECULAR MECHANISMS OF A TUMOR SUPPRESSOR

One of the key regulatory points of translation initiation is recruitment of the 43S preinitation complex to the 5′ mRNA cap by the eIF4F complex (eIF4A, eIF4E, and eIF4G). The tumor suppressor protein Pdcd4 has been shown to inhibit cap-dependent translation by interacting tightly with the RNA heli...

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Detalhes bibliográficos
Main Authors: Waters, Lorna C., Strong, Sarah L., Ferlemann, Eva, Oka, Ojore, Muskett, Frederick W., Veverka, Vaclav, Banerjee, Sreemoti, Schmedt, Thore, Henry, Alistair J., Klempnauer, Karl-Heinz, Carr, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089569/
https://ncbi.nlm.nih.gov/pubmed/21454508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166157
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