Neutralizing Interleukin-1β (IL-1β) Induces β-Cell Survival by Maintaining PDX1 Protein Nuclear Localization

The transcription factor PDX1 plays a critical role during β-cell development and in glucose-induced insulin gene transcription in adult β-cells. Acute glucose exposure leads to translocalization of PDX1 to the nucleoplasm, whereas under conditions of oxidative stress, PDX1 shuttles from the nucleus...

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Detalhes bibliográficos
Main Authors: Ardestani, Amin, Sauter, Nadine S., Paroni, Federico, Dharmadhikari, Gitanjali, Cho, Jae-Hyoung, Lupi, Roberto, Marchetti, Piero, Oberholzer, José, Conte, Julie Kerr, Maedler, Kathrin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089558/
https://ncbi.nlm.nih.gov/pubmed/21393239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210526
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