PCNA directs type 2 RNase H activity on DNA replication and repair substrates

Ribonuclease H2 is the major nuclear enzyme degrading cellular RNA/DNA hybrids in eukaryotes and the sole nuclease known to be able to hydrolyze ribonucleotides misincorporated during genomic replication. Mutation in RNASEH2 causes Aicardi–Goutières syndrome, an auto-inflammatory disorder that may a...

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Detalles Bibliográficos
Main Authors: Bubeck, Doryen, Reijns, Martin A. M., Graham, Stephen C., Astell, Katy R., Jones, E. Yvonne, Jackson, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089482/
https://ncbi.nlm.nih.gov/pubmed/21245041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq980
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