Haemophilus ducreyi Requires an Intact flp Gene Cluster for Virulence in Humans

An intact Haemophilus ducreyi flp operon is essential for microcolony formation in vitro. tadA is the 9th of 15 genes in the operon and has homology to NTPases of type IV secretion systems. Fifteen human volunteers were experimentally infected with both H. ducreyi 35000HP and the tadA mutant, 35000H...

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Bibliografiske detaljer
Main Authors: Spinola, Stanley M., Fortney, Kate R., Katz, Barry P., Latimer, Jo L., Mock, Jason R., Vakevainen, Merja, Hansen, Eric J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC308926/
https://ncbi.nlm.nih.gov/pubmed/14638812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.12.7178-7182.2003
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