Analysis of Virulence and Inflammatory Potential of Shigella flexneri Purine Biosynthesis Mutants

Several Shigella flexneri mutants with defects in aromatic amino acid and/or purine biosynthesis have been evaluated as vaccines in humans or in animal models. To be suitable as a vaccine, a mutant has to show virulence attenuation, minimal reactogenicity, and a good immunogenic potential in animal...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Cersini, Antonella, Martino, Maria Celeste, Martini, Irene, Rossi, Giacomo, Bernardini, Maria Lina
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2003
Fag:	Molecular Pathogenesis
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC308888/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14638790/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.12.7002-7013.2003
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