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Possible strategies for anti-fibrotic drug intervention in scleroderma

There are no approved drugs for treating the fibrosis in scleroderma (systemic sclerosis, SSc). Myfibroblasts within connective tissue express the highly contractile protein α–smooth muscle actin (α–SMA) and are responsible for the excessive synthesis and remodeling of extracellular matrix (ECM) cha...

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Dettagli Bibliografici
Autore principale: Leask, Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2011
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088791/
https://ncbi.nlm.nih.gov/pubmed/21484189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-011-0122-6
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