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Possible strategies for anti-fibrotic drug intervention in scleroderma
There are no approved drugs for treating the fibrosis in scleroderma (systemic sclerosis, SSc). Myfibroblasts within connective tissue express the highly contractile protein α–smooth muscle actin (α–SMA) and are responsible for the excessive synthesis and remodeling of extracellular matrix (ECM) cha...
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| Format: | Artigo |
| Jezik: | Inglês |
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Springer Netherlands
2011
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3088791/ https://ncbi.nlm.nih.gov/pubmed/21484189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-011-0122-6 |
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