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Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

Eukaryotic PIN (PilT N-terminal) domain proteins are ribonucleases involved in quality control, metabolism and maturation of mRNA and rRNA. The majority of prokaryotic PIN-domain proteins are encoded by the abundant vapBC toxin—antitoxin loci and inhibit translation by an unknown mechanism. Here we...

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Detalhes bibliográficos
Main Authors: Winther, Kristoffer S., Gerdes, Kenn
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088637/
https://ncbi.nlm.nih.gov/pubmed/21502523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019587108
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