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Extensive DNA-binding specificity divergence of a conserved transcription regulator

The DNA sequence recognized by a transcription regulator can be conserved across large evolutionary distances. For example, it is known that many homologous regulators in yeasts and mammals can recognize the same (or closely related) DNA sequences. In contrast to this paradigm, we describe a case in...

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Detalhes bibliográficos
Main Authors: Baker, Christopher R., Tuch, Brian B., Johnson, Alexander D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088634/
https://ncbi.nlm.nih.gov/pubmed/21498688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019177108
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