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Dose–response curve slope is a missing dimension in the analysis of HIV-1 drug resistance
HIV-1 drug resistance is a major clinical problem. Resistance is evaluated using in vitro assays measuring the fold change in IC(50) caused by resistance mutations. Antiretroviral drugs are used at concentrations above IC(50), however, and inhibition at clinical concentrations can only be predicted...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3088572/ https://ncbi.nlm.nih.gov/pubmed/21502494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018360108 |
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