Use of Pharmacokinetic-Pharmacodynamic Analyses To Optimize Therapy with the Systemic Antifungal Micafungin for Invasive Candidiasis or Candidemia

Echinocandins have become a first-line therapy for invasive candidiasis (IC). Using phase 3 trial data for patients with IC, pharmacokinetic-pharmacodynamic (PK-PD) relationships for efficacy for micafungin were examined. Micafungin exposures were estimated using a population pharmacokinetic model,...

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Detalhes bibliográficos
Main Authors: Andes, David, Ambrose, Paul G., Hammel, Jeffrey P., Van Wart, Scott A., Iyer, Varsha, Reynolds, Daniel K., Buell, Donald N., Kovanda, Laura L., Bhavnani, Sujata M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088268/
https://ncbi.nlm.nih.gov/pubmed/21300835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01430-10
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