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Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications
Inteins self-splice from precursor polypeptides to reconstitute functional proteins. Here we describe inteins as redox-responsive switches in bacteria. Regulation was achieved by engineering a disulfide bond between the intein’s catalytic cysteine and the flanking polypeptide. This interaction was v...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3087850/ https://ncbi.nlm.nih.gov/pubmed/21460844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2041 |
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