High Abundance Proteins Depletion vs Low Abundance Proteins Enrichment: Comparison of Methods to Reduce the Plasma Proteome Complexity

BACKGROUND: To date, the complexity of the plasma proteome exceeds the analytical capacity of conventional approaches to isolate lower abundance proteins that may prove to be informative biomarkers. Only complex multistep separation strategies have been able to detect a substantial number of low abu...

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Autori principali: Millioni, Renato, Tolin, Serena, Puricelli, Lucia, Sbrignadello, Stefano, Fadini, Gian Paolo, Tessari, Paolo, Arrigoni, Giorgio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087803/
https://ncbi.nlm.nih.gov/pubmed/21573190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019603
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