Development of an IL-15–autocrine CD8 T-cell leukemia in IL-15–transgenic mice requires the cis expression of IL-15Rα

IL-15 has growth-promoting effects on select lymphoid subsets, including natural killer (NK) cells, NK T cells, intraepithelial lymphocytes (IELs), CD8 T cells, and γδ-T cells. Constitutive expression of murine IL-15 in IL-15–transgenic mice was reported to cause T-NK leukemia. We investigated wheth...

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Autors principals: Sato, Noriko, Sabzevari, Helen, Fu, Song, Ju, Wei, Petrus, Michael N., Bamford, Richard N., Waldmann, Thomas A., Tagaya, Yutaka
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087530/
https://ncbi.nlm.nih.gov/pubmed/21304101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307504
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