G-CSF–mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands

Emergency mobilization of neutrophil granulocytes (neutrophils) from the bone marrow (BM) is a key event of early cellular immunity. The hematopoietic cytokine granulocyte-colony stimulating factor (G-CSF) stimulates this process, but it is unknown how individual neutrophils respond in situ. We show...

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Detalhes bibliográficos
Main Authors: Köhler, Anja, De Filippo, Katia, Hasenberg, Mike, van den Brandt, Cindy, Nye, Emma, Hosking, Martin P., Lane, Thomas E., Männ, Linda, Ransohoff, Richard M., Hauser, Anja E., Winter, Oliver, Schraven, Burkhart, Geiger, Hartmut, Hogg, Nancy, Gunzer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087483/
https://ncbi.nlm.nih.gov/pubmed/21224471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-308387
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