Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member of the nonreceptor protein-tyrosine phosphatase family, and functions in cell survival, proliferation, migration, and differentiation in many tissues. Here we report that loss of Ptpn11 in murine hematopoietic cell...

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Main Authors: Chan, Gordon, Cheung, Laurene S., Yang, Wentian, Milyavsky, Michael, Sanders, Ashley D., Gu, Shengqing, Hong, Wan Xing, Liu, Aurora X., Wang, Xiaonan, Barbara, Mary, Sharma, Tarun, Gavin, Joehleen, Kutok, Jeffery L., Iscove, Norman N., Shannon, Kevin M., Dick, John E., Neel, Benjamin G., Braun, Benjamin S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087477/
https://ncbi.nlm.nih.gov/pubmed/21398220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-319517
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