Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4(+)CD25(+)FoxP3(+) regulatory T cells

BACKGROUND AND PURPOSE: Phosphoinositide 3-kinase-γ (PI3Kγ) is implicated in many pathophysiological conditions, and recent evidence has suggested its involvement in colitis. In the present study, we investigated the effects of AS605240, a relatively selective PI3Kγ inhibitor, in experimental coliti...

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Detalhes bibliográficos
Main Authors: Dutra, RC, Cola, M, Leite, DFP, Bento, AF, Claudino, RF, Nascimento, AFZ, Leal, PC, Calixto, JB
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087137/
https://ncbi.nlm.nih.gov/pubmed/21244371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01226.x
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