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RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing

Alternative splicing contributes largely to cell differentiation and functional specification. We previously reported that the RNA-binding protein RBM4 antagonizes the activity of splicing factor PTB to modulate muscle cell–specific exon selection of α-tropomyosin. Here we show that down-regulation...

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Autores principales: Lin, Jung-Chun, Tarn, Woan-Yuh
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087008/
https://ncbi.nlm.nih.gov/pubmed/21518792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007131
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