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Evidence that Proteosome Inhibitors and Chemical Chaperones Can Rescue the Activity of Retinol Dehydrogenase 12 mutant T49M
Retinol dehydrogenase 12 (RDH12) is a microsomal enzyme that catalyzes the reduction of all-trans-retinaldehyde to all-trans-retinol when expressed in cells. Mutations in RDH12 cause severe retinal degeneration; however, some of the disease-associated RDH12 mutants retain significant catalytic activ...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086964/ https://ncbi.nlm.nih.gov/pubmed/21232531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.01.001 |
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