Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse

To test the hypothesis that tumor-associated macrophages (TAMs) enhance the growth and metastasis of human prostate cancer in the bone, we evaluated the effects of decreasing interleukin-6 (IL-6) production by tumor cells and TAMs in a mouse model of bone metastasis. Human PC-3MM2 cells that produce...

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Main Authors: Kim, Seung Wook, Kim, Jang Seong, Papadopoulos, John, Choi, Hyun Jin, He, Junqin, Maya, Marva, Langley, Robert R., Fan, Dominic, Fidler, Isaiah J, Kim, Sun-Jin
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086935/
https://ncbi.nlm.nih.gov/pubmed/21251905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2011.01.004
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