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Spindle Poisons and Cell Fate: A Tale of Two Pathways
Spindle poisons, such as paclitaxel and vinblastine, exert their potent anti-neoplastic effects through activation of the spindle assembly checkpoint (SAC), thereby arresting cells in mitosis. Unfortunately, only certain cancers are susceptible to these drugs, and many patients fail to respond to tr...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Pharmacology and Experimental Therapeutics
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086919/ https://ncbi.nlm.nih.gov/pubmed/21540474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mi.11.2.12 |
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