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Failure of Initial Therapy with Two Nucleosides and Efavirenz is Not Associated with Early Emergence of Mutations in the C-Terminus of HIV-1 Reverse Transcriptase

It is uncertain how often mutations in the connection or RNase H domains of HIV-1 reverse transcriptase (RT) emerge with failure of first-line antiretroviral therapy. Full-length RT sequences in plasma obtained pre-therapy and at virologic failure were compared in 53 patients on first-line efavirenz...

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Autori principali: Brehm, Jessica H., Lalama, Christina M., Hughes, Michael D., Haubrich, Richard, Riddler, Sharon A., Sluis-Cremer, Nicolas, Mellors, John W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086845/
https://ncbi.nlm.nih.gov/pubmed/21350368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e31820cf029
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