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TRC8, A KIDNEY CANCER-ASSOCIATED UBIQUITIN LIGASE, IS STEROL-REGULATED AND INTERACTS WITH LIPID AND PROTEIN BIOSYNTHETIC PATHWAYS
TRC8/RNF139 encodes an ER-resident E3-ubiquitin ligase that inhibits growth in a RING- and ubiquitylation-dependent manner. TRC8 also contains a predicted sterol-sensing domain. Here we report that TRC8 protein levels are sterol-responsive, and that it binds and stimulates ubiquitylation of the ER-a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086825/ https://ncbi.nlm.nih.gov/pubmed/20068067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0491 |
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