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Fluorescent labeling of tetracysteine-tagged proteins in intact cells

In this paper, we provide a general protocol for labeling proteins with the membrane-permeant fluorogenic biarsenical dye fluorescein arsenical hairpin binder–ethanedithiol (FlAsH-EDT(2)). Generation of the tetracysteine-tagged protein construct by itself is not described, as this is a protein-speci...

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Detalhes bibliográficos
Main Authors: Hoffmann, Carsten, Gaietta, Guido, Zürn, Alexander, Adams, Stephen R, Terrillon, Sonia, Ellisman, Mark H, Tsien, Roger Y, Lohse, Martin J
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086663/
https://ncbi.nlm.nih.gov/pubmed/20885379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2010.129
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