AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin Resistant Mice

AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabolic disorders in type 1 and type 2 diabetes. We demonstrate that AMPK interacts with and directly phosphorylates sterol regulatory element binding proteins (SREBP-1c and −2). Ser372 phosphorylation of SREBP-1...

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Detalhes bibliográficos
Main Authors: Li, Yu, Xu, Shanqin, Mihaylova, Maria, Zheng, Bin, Hou, Xiuyun, Jiang, Bingbing, Park, Ogyi, Luo, Zhijun, Lefai, Etienne, Shyy, John Y-J., Gao, Bin, Wierzbicki, Michel, Verbeuren, Tony J., Shaw, Reuben J., Cohen, Richard A., Zang, Mengwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086578/
https://ncbi.nlm.nih.gov/pubmed/21459323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.03.009
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