In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and Neprilysin

Metabolism of β-amyloid peptide (Aβ) is closely associated with the pathology and etiology of Alzheimer’s disease (AD). Our previous studies on aging primates and rodents have revealed that early life lead exposure increases the expression of the β-amyloid precursor protein (AβPP), elevates Aβ level...

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Hlavní autoři: Huang, Hui, Bihaqi, Syed Waseem, Cui, Liuxin, Zawia, Nasser H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086455/
https://ncbi.nlm.nih.gov/pubmed/21315759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2011.02.001
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