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Bivalirudin is a Dual Inhibitor of Thrombin and Collagen-Dependent Platelet Activation in Patients Undergoing Percutaneous Coronary Intervention

BACKGROUND: Bivalirudin, a direct thrombin inhibitor, is a widely used adjunctive therapy in patients undergoing percutaneous intervention (PCI). Thrombin is a highly potent agonist of platelets and activates the protease-activated receptors, PAR1 and PAR4, but it is not known whether bivalirudin ex...

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Main Authors: Kimmelstiel, Carey, Zhang, Ping, Kapur, Navin K., Weintraub, Andrew, Krishnamurthy, Barath, Castaneda, Vilma, Covic, Lidija, Kuliopulos, Athan
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086141/
https://ncbi.nlm.nih.gov/pubmed/21364148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCINTERVENTIONS.110.959098
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