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Enhanced activity of antisense phosphorothioate oligos against Leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target intervention under altered growth conditions

Leishmania, a parasitic protozoan, infects human macrophages, often causing severe morbidity and mortality. The pathogenic form of this parasite, the amastigote, lives inside the acidic phagolysosomes of infected macrophages. In our attempt to develop anti-miniexon phosphorothioate oligodeoxyribonuc...

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Main Authors: Mishra, Manjari, Porter-Kelley, Johanna M., Singh, Pramod K., Bennett, Jabbar R., Chaudhuri, Gautam
Formato: Artigo
Idioma:Inglês
Publicado: 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085994/
https://ncbi.nlm.nih.gov/pubmed/11585054
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