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Disruption of Pyridine Nucleotide Redox Status During Oxidative Challenge at Normal and Low-Glucose States: Implications for Cellular Adenosine Triphosphate, Mitochondrial Respiratory Activity, and Reducing Capacity in Colon Epithelial Cells

We recently demonstrated that menadione (MQ), a redox cycling quinone, mediated the loss of mitochondrial glutathione/glutathione disulfide redox balance. In this study, we showed that MQ significantly disrupted cellular pyridine nucleotide (NAD(+)/NADH, NADP(+)/NADPH) redox balance that compromised...

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Библиографические подробности
Главные авторы: Circu, Magdalena L., Maloney, Ronald E., Aw, Tak Yee
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc. 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085944/
https://ncbi.nlm.nih.gov/pubmed/21083422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3489
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