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The Role of LKB1 in the Pathogenesis of Skin and Other Epithelial Cancers
LKB1 acts as a master kinase, with its major protein targets being the family of AMPKs. Through activation of multiple signaling pathways, LKB1’s main physiologic functions involve regulating cellular growth, metabolism, and polarity. Germline mutations in LKB1 result in Peutz-Jeghers Syndrome, a ra...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3085567/ https://ncbi.nlm.nih.gov/pubmed/21450399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.01.014 |
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