Immunological and Clinical Effects of Vaccines Targeting p53-Overexpressing Malignancies

Approximately 50% of human malignancies carry p53 mutations, which makes it a potential antigenic target for cancer immunotherapy. Adoptive transfer with p53-specific cytotoxic T-lymphocytes (CTL) and CD4(+) T-helper cells eradicates p53-overexpressing tumors in mice. Furthermore, p53 antibodies and...

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Bibliografische gegevens
Hoofdauteurs: Vermeij, R., Leffers, N., van der Burg, S. H., Melief, C. J., Daemen, T., Nijman, H. W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi Publishing Corporation 2011
Onderwerpen:
Review Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085500/
https://ncbi.nlm.nih.gov/pubmed/21541192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/702146
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