Structure and Control of the Actin Regulatory WAVE Complex

Members of the Wiskott-Aldrich Syndrome Protein (WASP) family control cytoskeletal dynamics by promoting actin filament nucleation by the Arp2/3 complex. The WASP relative, WAVE, regulates lamellipodia formation within a 400 kDa, hetero-pentameric WAVE Regulatory Complex (WRC). The WRC is inactive t...

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Bibliografiske detaljer
Main Authors: Chen, Zhucheng, Borek, Dominika, Padrick, Shae B., Gomez, Timothy S., Metlagel, Zoltan, Ismail, Ayman, Umetani, Junko, Billadeau, Daniel D., Otwinowski, Zbyszek, Rosen, Michael K.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085272/
https://ncbi.nlm.nih.gov/pubmed/21107423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09623
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