Treatment with the phosphodiesterase type 4 inhibitor rolipram fails to inhibit blood brain barrier disruption in MS

Rolipram, a prototypic phosphodiesterase-4 inhibitor is highly effective in suppressing Th1 autoimmunity in multiple animal models, including experimental autoimmune encephalomyelitis (EAE). Additionally, Rolipram has been extensively studied as a potential neuroprotective agent. Based on its anti-i...

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Autori principali: Bielekova, Bibiana, Richert, Nancy, Howard, Thomas, Packer, Amy N., Blevins, Gregg, Ohayon, Joan, McFarland, Henry F., Stürzebecher, Claus-Steffen, Martin, Roland
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085182/
https://ncbi.nlm.nih.gov/pubmed/19776093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1352458509345903
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