Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy

BACKGROUND: Enhancer of zeste homolog 2 is a component of the Polycomb repressive complex 2 that mediates chromatin-based gene silencing through trimethylation of lysine 27 on histone H3. This complex plays vital roles in the regulation of development-specific gene expression. DESIGN AND METHODS: In...

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Main Authors: Sasaki, Daisuke, Imaizumi, Yoshitaka, Hasegawa, Hiroo, Osaka, Akemi, Tsukasaki, Kunihiro, Choi, Young Lim, Mano, Hiroyuki, Marquez, Victor E., Hayashi, Tomayoshi, Yanagihara, Katsunori, Moriwaki, Yuji, Miyazaki, Yasushi, Kamihira, Shimeru, Yamada, Yasuaki
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084918/
https://ncbi.nlm.nih.gov/pubmed/21228036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.028605
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