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Synthesis of Saturated 1,4-Benzodiazepines via Pd-Catalyzed Carboamination Reactions

[Image: see text] A new synthesis of 1,4-benzodiazepines and 1,4-benzodiazepin-5-ones is reported. The Pd-catalyzed coupling ofN-allyl-2-aminobenzylamine derivatives with aryl bromides affords the heterocyclic products in good yield, and substrates bearing allylic methyl groups are transformed toc i...

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Detalhes bibliográficos
Main Authors: Neukom, Joshua D., Aquino, Alvin S., Wolfe, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084890/
https://ncbi.nlm.nih.gov/pubmed/21446677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200429a
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