Molecular Mode of Action and Role of TP53 in the Sensitivity to the Novel Epothilone Sagopilone (ZK-EPO) in A549 Non-Small Cell Lung Cancer Cells

Sagopilone, an optimized fully synthetic epothilone, is a microtubule-stabilizing compound that has shown high in vitro and in vivo activity against a broad range of human tumor models. We analyzed the differential mechanism of action of sagopilone in non-small cell lung cancer cell lines in vitro....

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Bibliographic Details
Main Authors: Winsel, Sebastian, Sommer, Anette, Eschenbrenner, Julia, Mittelstaedt, Kevin, Klar, Ulrich, Hammer, Stefanie, Hoffmann, Jens
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084814/
https://ncbi.nlm.nih.gov/pubmed/21559393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019273
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