Receptor Activator of NF-kB (RANK) Expression in Primary Tumors Associates with Bone Metastasis Occurrence in Breast Cancer Patients

BACKGROUND: Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity. RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited b...

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Main Authors: Santini, Daniele, Schiavon, Gaia, Vincenzi, Bruno, Gaeta, Laura, Pantano, Francesco, Russo, Antonio, Ortega, Cinzia, Porta, Camillo, Galluzzo, Sara, Armento, Grazia, La Verde, Nicla, Caroti, Cinzia, Treilleux, Isabelle, Ruggiero, Alessandro, Perrone, Giuseppe, Addeo, Raffaele, Clezardin, Philippe, Muda, Andrea Onetti, Tonini, Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084800/
https://ncbi.nlm.nih.gov/pubmed/21559440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019234
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