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Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization
Acetyl group turnover on specific lysine ε-amino groups of the core chromosomal histones regulates DNA accessibility function, and the acetylating and deacetylating enzymes that govern the turnover provide important targets for the development of anti-cancer drugs. Histone deacetylase (HDAC) inhibit...
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Main Authors: | , , , , , |
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Formáid: | Artigo |
Teanga: | Inglês |
Foilsithe: |
2009
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Ábhair: | |
Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084600/ https://ncbi.nlm.nih.gov/pubmed/19652528 |
Clibeanna: |
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