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Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization

Acetyl group turnover on specific lysine ε-amino groups of the core chromosomal histones regulates DNA accessibility function, and the acetylating and deacetylating enzymes that govern the turnover provide important targets for the development of anti-cancer drugs. Histone deacetylase (HDAC) inhibit...

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Sonraí Bibleagrafaíochta
Main Authors: Bandyopadhyay, Keya, Banères, Jean-Louis, Martin, Aimée, Blonski, Casimir, Parello, Joseph, Gjerset, Ruth A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084600/
https://ncbi.nlm.nih.gov/pubmed/19652528
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