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Complement factor B polymorphism 32W protects against age-related macular degeneration

PURPOSE: The 32Q (rs641153; A) and 32W (rs12614; T) variants of complement factor B (CFB) cause less efficient complement activation in vitro than the common 32R variant. This is thought to be the reason that the 32Q variant is associated with decreased risk of age-related macular degeneration (AMD)...

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Hlavní autoři: Hughes, Anne E., Mullan, Gemma M., Bradley, Declan T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084221/
https://ncbi.nlm.nih.gov/pubmed/21541267
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