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Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape

The fitness landscape captures the relationship between genotype and evolutionary fitness and is a pervasive metaphor used to describe the possible evolutionary trajectories of adaptation. However, little is known about the actual shape of fitness landscapes, including whether valleys of low fitness...

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מידע ביבליוגרפי
Main Authors: Kvitek, Daniel J., Sherlock, Gavin
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084205/
https://ncbi.nlm.nih.gov/pubmed/21552329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002056
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