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The Valley of Death: Reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment

The fitness landscape is a powerful metaphor for describing the relationship between genotype and phenotype for a population under selection. However, empirical data as to the topography of fitness landscapes are limited, owing to difficulties in measuring fitness for large numbers of genotypes unde...

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Bibliografische gegevens
Gepubliceerd in:Genomics
Hoofdauteurs: Chiotti, Kami, Kvitek, Daniel J., Schmidt, Karen, Koniges, Greg, Schwartz, Katja, Donckels, Elizabeth A., Rosenzweig, Frank, Sherlock, Gavin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454348/
https://ncbi.nlm.nih.gov/pubmed/25449178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2014.10.011
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