Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines

Hepatitis C virus (HCV) is hepatotropic and only infects humans and chimpanzees. Consequently, an immunocompetent small animal model is lacking. The restricted tropism of HCV likely reflects specific host factor requirements. We investigated if dominant restriction factors expressed in non-liver or...

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Main Authors: Frentzen, Anne, Hüging, Kathrin, Bitzegeio, Julia, Friesland, Martina, Haid, Sibylle, Gentzsch, Juliane, Hoffmann, Markus, Lindemann, Dirk, Zimmer, Gert, Zielecki, Florian, Weber, Friedemann, Steinmann, Eike, Pietschmann, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084199/
https://ncbi.nlm.nih.gov/pubmed/21552323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002029
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