Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines

Hepatitis C virus (HCV) is hepatotropic and only infects humans and chimpanzees. Consequently, an immunocompetent small animal model is lacking. The restricted tropism of HCV likely reflects specific host factor requirements. We investigated if dominant restriction factors expressed in non-liver or...

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Detalhes bibliográficos
Main Authors: Frentzen, Anne, Hüging, Kathrin, Bitzegeio, Julia, Friesland, Martina, Haid, Sibylle, Gentzsch, Juliane, Hoffmann, Markus, Lindemann, Dirk, Zimmer, Gert, Zielecki, Florian, Weber, Friedemann, Steinmann, Eike, Pietschmann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084199/
https://ncbi.nlm.nih.gov/pubmed/21552323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002029
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