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Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy
Protein kinase A (PKA) is a ubiquitous phosphoryl transferase that mediates hundreds of cell signaling events. During turnover, its catalytic subunit (PKA-C) interconverts between three major conformational states (open, intermediate, and closed) that are dynamically and allosterically activated by...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084134/ https://ncbi.nlm.nih.gov/pubmed/21471451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102701108 |
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