Alternative mechanisms of receptor editing in autoreactive B cells

Pathogenic anti-DNA antibodies expressed in systemic lupus erythematosis bind DNA mainly through electrostatic interactions between the positively charged Arg residues of the antibody complementarity determining region (CDR) and the negatively charged phosphate groups of DNA. The importance of Arg i...

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Autores principales: Kalinina, Olga, Doyle-Cooper, Colleen M., Miksanek, Jennifer, Meng, Wenzhao, Prak, Eline Luning, Weigert, Martin G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084116/
https://ncbi.nlm.nih.gov/pubmed/21471456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019389108
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