Alternative mechanisms of receptor editing in autoreactive B cells

Pathogenic anti-DNA antibodies expressed in systemic lupus erythematosis bind DNA mainly through electrostatic interactions between the positively charged Arg residues of the antibody complementarity determining region (CDR) and the negatively charged phosphate groups of DNA. The importance of Arg i...

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Bibliografiske detaljer
Main Authors: Kalinina, Olga, Doyle-Cooper, Colleen M., Miksanek, Jennifer, Meng, Wenzhao, Prak, Eline Luning, Weigert, Martin G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084116/
https://ncbi.nlm.nih.gov/pubmed/21471456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019389108
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